Can Augmentation of Clozapine with Paliperidone Improve Negative Symptoms in Schizophrenia Patients with Partial Response to Treatment: A Case Series 2

Clozapine is the only antipsychotic medication that has definitely shown to be effective in treating refractory schizophrenia. Clozapine is typically the medication of choice in schizophrenic patients with a partial response to treatment. When clozapine fails to elicit a full treatment response, augmentation strategies are then explored. It is important to note, however, that in treatment resistant schizophrenic patients, the addition of a second antipsychotic is frequently preferred as an augmentation method. Consistent positive results could not be obtained with previous augmentation strategies.